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Joe Biden has authorised Ukraine to begin firing US-supplied rockets deep into Russia - as Sir Keir Starmer prepares to push for "further support" for Kyiv at the G20 summit.
Mr Biden's policy shift means Kyiv will now be able to use Army Tactical Missile Systems (ATACMS) for long-range attacks, two American officials have told Sky News' US partner network NBC News.
Ukraine plans to conduct its first such attacks in the coming days, the sources said, without revealing details due to operational security concerns.
The US has eased restrictions on the use of ATACMS, which have a range of up to 190 miles, after Russia began deploying North Korean ground troops to supplement its own forces in the conflict.
The development was condemned by Biden officials as a possible expansion of the war.
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A Russian politician and the son of president-elect Donald Trump have both likened the move to risking a third world war.
Maria Butina told the Reuters news agency: "These guys, Biden's administration, is trying to escalate the situation to the maximum while they still have power and are still in office.
"I have a great hope that Trump will overcome this decision if this has been made because they are seriously risking the start of World War Three which is not in anybody's interest."
Meanwhile, Donald Trump Jr wrote on X: "The Military Industrial Complex seems to want to make sure they get World War 3 going before my father has a chance to create peace and save lives... Imbeciles!"
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The outgoing Biden administration's move comes as there are concerns about the level of support the Trump White House may be willing to give Ukraine.
Mr Trump has previously vowed to limit US support for Ukraine and end its war with Russia.
In an evening address after Kyiv was given permission to fire deep into Russia, Ukrainian President Volodymyr Zelenskyy said: "Today, there's a lot of talk in the media about us receiving permission for respective actions. But strikes are not carried out with words. Such things are not announced. Missiles will speak for themselves. They certainly will."
Back in September, Russian President Vladimir Putin said if the US were to lift the ban on long-range missile use it would be seen as NATO's "direct participation" in the war.
He added: "This, of course, will significantly change the very essence, the very nature of the conflict."
Meanwhile, the UK prime minister has said he has "no plans" to speak with the Russian president as world leaders gather for the G20 summit in Rio de Janeiro.
Mr Putin will not be attending the two-day summit which starts on Monday after saying in October that his presence would "disrupt the normal work of this forum". Russia's foreign minister Sergei Lavrov will be attending instead.
It will take place days after German Chancellor Olaf Scholz spoke to Mr Putin on what was the Russian leader's first publicly announced conversation with the sitting head of a major Western power in nearly two years.
Asked if he had any plans to make a similar call, Sir Keir said: "It's a matter for Chancellor Scholz who he speaks to. I have no plans to speak to Putin."
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Speaking to reporters while on his way to the summit, he added: "We are coming up to the 1,000th day of this conflict on Tuesday.
"That's 1,000 days of Russian aggression, 1,000 days of huge impact and sacrifice in relation to the Ukrainian people and recently we've seen the addition of North Korean troops working with Russians which does have serious implications.
"I think on one hand it shows the desperation of Russia, but it's got serious implications for European security [...] and for Indo-Pacific security and that's why I think we need to double down on shoring up our support for Ukraine and that's top of my agenda for the G20.
"There's got to be full support as long as it takes and that certainly is top of my agenda, shoring up that further support for Ukraine."
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The latest developments come after Russia launched a large-scale attack on Ukraine on Sunday, with Mr Zelenskyy claiming Moscow had launched a total of 120 missiles and 90 drones.
Two major strikes, which left a total of 18 people dead, hit a residential building in the northeastern city of Sumy as well as energy infrastructure across Ukraine, prompting emergency power cuts.
Hours later, Moscow mayor Sergei Sobyanin said Russia's air defence units had destroyed a drone heading towards the city.
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